Publications

  • Gaur V, Wyatt HDM, Komorowska W, Szczepanowski RH, de Sanctis D, Gorecka KM, West SC, Nowotny M. Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease. 2015. Cell Reports, 10.
  • Miętus M, Nowak E, Jaciuk M, Kustosz P, Studnicka J, Nowotny M. Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding. 2014. Nucleic Acids Res, 42(16), 10762-75.
  • Tomecki R, Drazkowska K, Kucinski I, Stodus K, Szczesny RJ, Gruchota J, Owczarek EP, Kalisiak K, Dziembowski A . Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target. 2014. Nucleic Acids Res., 42(2), 1270-90.
  • Nowak E, Miller JT, Bona MK, Studnicka J, Szczepanowski RH, Jurkowski J, Le Grice SFJ, Nowotny M. Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. 2014. Nature Structural & Molecular Biology, 21(4), 389-96.
  • Smietanski M, Werner M, Purta E, Kaminska KH, Stepinski J, Darzynkiewicz E, Nowotny M, Bujnicki JM. Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation. 2014. Nat Commun, 5, 3004.
  • Górecka KM, Komorowska W, Nowotny M. Crystal structure of RuvC resolvase in complex with Holliday junction substrate. 2013. Nucleic Acids Res, 41(21), 9945-55.
  • Chon H, Sparks JL, Rychlik M, Nowotny M, Burgers PM, Crouch RJ, Cerritelli SM. RNase H2 roles in genome integrity revealed by unlinking its activities. 2013. Nucleic Acids Res, 41(5), 3130-43.
  • Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M. Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid. 2013. Nucleic Acids Res, 41(6), 3874-87.
  • Figiel M, Chon H, Cerritelli SM, Cybulska M, Crouch RJ, Nowotny M. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects. 2011. J Biol Chem, 286(12), 10540-10550.
  • Rosta E, Nowotny M, Yang W, Hummer G. Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations. 2011. J Am Chem Soc., 133(23), 8934-8941.
  • Jaciuk M, Nowak E, Skowronek K, Tańska A, Nowotny M. Structure of UvrA nucleotide excision repair protein in complex with modified DNA. 2011. Nat Struct Mol Biol, 18, 191-7.
  • Rychlik MP, Chon H, Cerritelli SM, Klimek P, Crouch RJ, Nowotny M. Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage. 2010. Mol Cell, 40, 658-70.
  • Nowotny M, Yang W. Structural and functional modules in RNA interference. 2009. Curr Opin Struct Biol, 19, 286-93.
  • Nowotny M. Retroviral integrase superfamily: the structural perspective. 2009. EMBO Rep, 10, 144-51.
  • Nowotny M, Cerritelli SM, Ghirlando R, Gaidamakov SA, Crouch RJ, Yang W. Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. 2008. EMBO J. 27(7):1172-81.
  • Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W. Structure of human RNase H1 complexed with an RNA/DNA hybrid: Insight into HIV Reverse Transcription. 2007. Mol. Cell; 28:264-276.
  • Nowotny M, Yang W. Stepwise analyses of metal Ions in RNase H catalysis: From substrate destabilization to product release. 2006. EMBO J. 25:1924-33.
  • Nowotny M, Gaidamakov SA, Crouch RJ, Yang W. Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specifi city and metal-dependent catalysis. 2005. Cell. 121:1005-16.
  • Nowak E, Brzuszkiewicz A, Dauter M, Dauter Z, Rosenbaum G. To scavenge or not to scavenge: that is the question. 2009. Acta Cryst. D65, 1004-06.
  • Brzuszkiewicz A, Nowak E, Dauter M, Dauter Z, Cieslinski H, Dlugolecka A, Kur J. Structure of EstA esterase from psychrotrophic Pseudoalteromonas sp. 643A covalently inhibited by monoethylphosphonate. 2009. Acta Cryst. F65, 862-865.
  • King-Scott J, Nowak E, Mylonas E, Panjikar S, Rossle M, Svergun DI, Tucker PA. The structure of a full-length response regulator from Mycobacterium tuberculosis a stabilized domain swapped, activated state. 2007. J. Biol. Chem. 282, 37717-29.
  • Tucker PA, Nowak E, Morth JP. Two-component system of Mycobacterium tuberculosis – structure based approaches. 2007. Methods Enzymol. 423 : 479-501.
  • Nowak E, Panjikar S, Konarev P, Svergun DI, Tucker PA. The Structural Basis of Signal Transduction for the Response Regulator PrrA from Mycobacterium tuberculosis. 2006. J. Biol. Chem. 281: 9659 – 66.
  • Nowak E, Panjikar S, Morth JP, Jordanova R, Svergun DI, Tucker PA. Structural and functional aspects of the sensor histidine kinase PrrB from Mycobacterium tuberculosis. 2006. Structure 14, 275-285.
  • Morth JP, Gosmann S, Nowak E, Tucker PA. A novel two-component system found in Mycobacterium Tuberculosis. 2005. FEBS Lett.  579, 4145-48.
  • Szyrszyng M, Nowak E, Gdaniec M, Milewska MJ, Polonski T. Optical activity of the guest azobenzene molecule generated by inclusion complexation by steroidal bile acid. 2004. Tetrahedron 15, 3257-61.
  • Szyrszyng M, Nowak E, Gdaniec M, Milewska MJ, Polonski T. Optical activity of benzophenone and thiobenzophenone generated by spontaneous crystallization and inclusion complexation with cholic acid. 2004. Tetrahedron: Asymmetry 15, 103-107.
  • Gdaniec M, Nowak E, Milewska MJ, Połoński T. (S)-trans -Cyklohexane-1,2-dicarboximide. 2002. Acta Cryst. C58, 661-662.
  • Weiss MS, Panjikar S, Nowak E, Tucker P. Metal binding to porcine elastase: calcium or not calcium.  2002. Acta Cryst. D58, 1407-12.
  • Dega-Szafran Z, Antkowiak A, Grunwald-Wyspiańska M, Nowak E, Kosturkiewicz Z. Crystal structure of bis(N-methylmorpholine) hydrochloride, FTIR and NMR studies of 1:1 and 2:1 complexes of N-methylmorpholine betaine with mineral acids.  2002. J. Mol. Struct. 605, 13, 309-317.
  • Dega-Szafran Z, Szafran M, Antkowiak A, Grunwald-Wyspiańska M, Nowak E, Gdaniec M, Kosturkiewicz Z, Structure of and hydrogen bonding in a 3:2 inclusion compound of N-methylmorpholine betaine hydrochloride with acetonitrile.  2002. J. Mol. Struct. 605, 13, 325-330.
  • Szyrszyng M, Nowak E, Gdaniec M, Milewska MJ, Herman A, Połoński T. Circular Dichroism Spectra of the Achiral Guest N-Aryl-N-nitrosoamines in the Crystal Matrices of Cholic Acids.  2001. J. Org. Chem. 66, 22, 7380-84.
  • Połoński T, Szyrszyng M, Gdaniec M, Nowak E, Herman A. Absolute sense of twist of the benzil molecule in its enantiomorphous crystals and inclusion complexes with optically active hosts. 2001. Tetrahedron: Asymmetry 12, 797-800.
  • Sączewski F, Kobierska E, Dębowski T, Charakchiewa-Minol S, Morkosz M, Gdaniec M, Nowak E.  Synthesis, structure and binding of some 2-imidazolines to rat brain a1- and a2-adrenergic receptors. 2000. Archiv der Pharmazie, Pharmaceutical and Medicinal Chemistry 333, 12, 425-430.
  • Sączewski F, Kobierska E, Dębowski T, Trzeciak H, Krzystanek E, Krzystanek M, Gdaniec M, Nowak E.  Circulatory Activities of Some 2-Imidazline Derivatives in Wista Rats. 2000. Arterial Hypertension  4, 3, 173-180.
  • Nowak E,  Gdaniec M,  Połoński T.  The Crystal Structure of the 2:1 Cholic Acid –Benzophenone Clathrate. 2000. J. Incl. Phenom. 37, 155-169.
  • Nowak E,  Gdaniec M,  Gierczyk B,  Urbaniak W.  Synthesis and Crystal Structure of bis(2-iminopent-2-en-4onato)nickel(II). 1999. Polish. J. Chem. 73, 1757-62.
  • Cadelnic I,  Shova S,  Simonov Yu A,  Gdaniec M,  Cendrowska E,  Jovmir T, Turta C, Bulhac I. Crystal and Molecular Structure of [Fe3O(C6H5COO)6(H2O)3] – 3-Cl-PyH – (CH3C6H4SO3)2 – 2H2O. 1997. Polish J. Chem. 71, 501-508.