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ProBiostructures is changing for you.
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Through years of supporting lead optimization in drug discovery field we have expanded our expertise in 3-D structure determination of nucleic acid-based drugs with proteins.

To better represent our expertise we have become Leaderna Biostructures.

We provide a complete Gene-to-Structure approach comprising of X-ray crystallography and cryo-EM techniques complemented with biophysical and biochemical analysis.

Services

Leaderna offers a complete range of X-ray crystallography and cryo-EM techniques, called Gene-to-Structure, complemented with biophysical and biochemical characterization of target-ligand interaction.


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We provide optimized services using the highest scientific standards in the competitive field of structural biology.

About us

gleevec_overal_probiostructure_bgr
PDB ID:1IEP

The success of Leaderna Biostructures derives from the highest level of expertise in science, advanced skills, and the excellent quality of services, provided formerly as ProBiostructures.

Over the years of supporting lead optimization process in drug discovery, we have established a well-grounded position in the field of structure-based drug design (SBDD) projects. In the course of cooperation with leading pharmaceutical companies from Europe (e.g., UbiQ Bio, Selvita, Celon Pharma, OncoArendi Therapeutics, Adamed) and from the United States (IONIS Pharmaceuticals), our services have supported drug discovery efforts for such diseases as cancer, asthma, and depression.

Over time of extensive collaboration with Ionis Pharmaceuticals, a world leader in RNA-targeted therapeutics, we expanded our expertise in structure determination of nucleic acid-based drugs with proteins.
To reflect our full repertoire of services with emphasis on specialization in nucleic acid-based molecules we have become Leaderna Biostructures.

As Leaderna we offer a full range of services in structural analysis, called Gene-to-Structure approach, for proteins targeted by both small ligands and nucleic acids.

In addition to profitable commercial projects, Leaderna also scientifically cooperates with companies from the biotechnology and pharmaceutical sectors. Such collaborations are an investment in promoting the laboratory by presenting scientific potential, expertise in R&D projects, and a flexible approach to cooperation with industry.

We closely collaborate with Polish science centers, among others, the International Institute of Molecular and Cell Biology in Warsaw, the leading bioscience institute in Poland.

With the support of renowned experts with distinguished scientific experience in the field of structural biology we are able to run challenging projects.

The team

Our team consists of people with great knowledge and intuition.

With a passion for structural biology, we provide novel and unique solutions to support the dynamic development of new drugs.

Team

Paweł Kustosz

Paweł Kustosz

Pawel is a founder and CEO of Leaderna Biostructures. He is a graduate of the University of Adam Mickiewicz in biotechnology as well as the Warsaw School of Economics in project management. He acquired his experience at the Mossakowski Medical Research Center of the Polish Academy of Sciences. There he also cooperated with the Central Clinical Hospital Ministry of Interior in Warsaw. During his work at the International Institute of Molecular and Cell Biology in Warsaw in the Laboratory of Protein Structure headed by dr. Marcin Nowotny, in 2015 he organized the IIMCB Structure Biology Center named ProBiostructures. After over 4 years of success in running a business, in 2019 he spin-off the company from IIMCB and named it Leaderna Biostructures.

Elżbieta Nowak, Ph.D.

Elżbieta Nowak, Ph.D.

Elzbieta is an experienced crystallographer and a laboratory work coordinator in Leaderna Biostructures. She uses X-ray diffraction techniques to solve crystal structures of various proteins and nucleic acids of biological and medical relevance. She gained her experience at the highly acclaimed Advanced Photon Source at National Institutes of Health (NIH) in the US and at Deutsches Elektronen-Synchrotron (DESY) at The European Molecular Biology Laboratory (EMBL) in Hamburg. Currently she works in the Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology in Warsaw. The object of her research are enzymes involved in reverse transcription and DNA repair processes. These processes, although very different, are carried out with proteins that can specifically recognize nucleic acids. Her research is focused on understanding the molecular mechanisms of these processes.

Mariusz Czarnocki-Cieciura, Ph.D.

Mariusz Czarnocki-Cieciura, Ph.D.

Mariusz is a structural biologist experienced in single particle cryo-EM, X-ray crystallography and various biophysical methods for analysis of proteins and protein complexes. His scientific interests are focused around mechanisms and structural aspects of gene expression regulation in Eukaryotes. He received his PhD from the University of Warsaw in 2015 and is currently a postdoctoral researcher in the Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology in Warsaw. He was involved in the organization of cryo-electron microscopy laboratory at IIMCB Warsaw and he has experience in all steps of single particle cryo-EM, from sample preparation to data processing. He gained his experience with cryo-electron microscopy during his everyday work at IIMCB, during his visit at the European Molecular Biology Laboratory (EMBL) in Grenoble, and as an user of several cryo-EM facilities in Europe. He also attended several cryo-EM trainings and workshops, covering operation of all ranges of microscopes (Tecnai T12 at IIMCB Warsaw, 2017; Glacios at CeNT, Warsaw, 2019; Krios at Solaris, Kraków, 2019) and cryo-EM model building (Madrid, 2019).

Partners

Our clients can expand the range of crystallography services with the help of our partners and take advantage of joint offer.