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We are a professional partner responsible for structural biology and have experience in supporting drug discovery projects in hit to lead and lead optimization phases as well as other scientific endeavors.

A remarkable advantage is unique expertise in the crystallization of protein-nucleic acid complexes and the offer with a full range of X-ray crystallography and cryo-EM research called "gene to structure" enriched with biophysical and biochemical analysis.

ProBiostructures offers the best quality at competitive prices

About us

gleevec_overal_probiostructure_bgr
PDB ID:1IEP

The success of ProBiostructures derives from the highest level of expertise in science, advanced skills, and the excellent quality of services that are rendered. It offers the extensive experience of top scientists in biomedicine research form the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), Poland’s leading research institution. IIMCB was established under an international agreement between the Polish government and UNESCO. The principles of operation are based on ideas from the best research institutes in the world which also makes it a good business partner.

The co-founder and the CSO of ProBiostructures is dr. Marcin Nowotny, a renown crystallographer with significant scientific output (publications in journals such as Cell, Molecular Cell, EMBO Journal, Nature Structural Molecular Biology, Nature Communications). He is a recipient of prestigious research grants, such as EMBO Installation Grant, ERC Starting Grant, Wellcome Trust International Senior Research Fellowship and the Howard Hughes International Early Career Scientist Award. Between 2003 and 2008, he was a postdoctoral research fellow in the group of Wei Yang Laboratory, National Institutes of Health.

ProBiostructures cooperates closely with leading pharmaceutical companies in central Europe (e.g., Selvita, Celon Pharma, OncoArendi Therapeutics, Adamed) and with UbiQ Bio in the Netherlands and IONIS Pharmaceuticals in the United States. The results have supported drug discovery efforts for such diseases as cancer, asthma, and depression. ProBiostructures solved a crystal structure of OncoArendi’s OATD-01 compound with a target protein. The compound is undergoing clinical trials and in the case of positive results will be the first sarcoidosis drug on the market, with a new mechanism of action (first in class).

In addition to profitable commercial projects, ProBiostructures also scientifically cooperates with foreign companies from the biotechnology and pharmaceutical sectors. Such collaborations are an investment in promoting the laboratory by presenting scientific potential, expertise in R&D projects, and a flexible approach to cooperation with industry.

The team

Team

Dr Marcin Nowotny

Dr Marcin Nowotny

Dr. Marcin Nowotny (Chief Scientific Officer), head of the Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology in Warsaw, is a co-founder and the Principal Investigator of PRO Biostructures. He is a co-author of over 30 scientific publications (such as: Cell, Molecular Cell, EMBO Journal, Nature Structural Molecular Biology, Nature Communications). Dr. Nowotny has received prestigious research grants, such as EMBO Installation Grant, the ERC Starting Grant, the Wellcome Trust International Senior Research Fellowship (twice) and the Howard Hughes International Early Career Scientist Award. Between 2003 and 2008, he was a postdoctoral research fellow in the group of Wei Yang Laboratory, National Institutes of Health.

Paweł Kustosz

Paweł Kustosz

Pawel Kustosz (Chief Executive Officer) is a co-founder and a manager of PRO Biostructures. He is a graduate of the University of Adam Mickiewicz in biotechnology as well as the Warsaw School of Economics in project management. He acquired his experience at the Mossakowski Medical Research Center of the Polish Academy of Sciences. There he also cooperated with the Central Clinical Hospital Ministry of Interior in Warsaw. During his work at the Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology in Warsaw, he organized the IIMCB Structure Biology Center named PRO Biostructures.

Dr Elżbieta Nowak

Dr Elżbieta Nowak

Dr. Elzbieta Nowak (Chief Operating Officer) is an experienced crystallographer and a laboratory work coordinator in PRO Biostructures. She uses X-ray diffraction techniques to solve crystal structures of various proteins and nucleic acids of biological and medical relevance. She gained her experience at the highly acclaimed Advanced Photon Source at National Institutes of Health (NIH) in the US and at Deutsches Elektronen-Synchrotron (DESY) at The European Molecular Biology Laboratory (EMBL) in Hamburg. Currently she works in the Laboratory of Protein Structure at the International Institute of Molecular and Cell Biology in Warsaw.

Partners

Our clients can expand the range of crystallography services with the help of our partners and take advantage of joint offer.

 

The Nencki Institute of Experimental Biology, Centre for Neurobiology

1. Laboratory of Tissue Structure and Function Imaging.
2. Laboratory of Brain Imaging.
3. Laboratory of Preclinical Research of a Higher Standard.
4. Laboratory of Animal Models.
5. Laboratory of Molecular Neurobiology.